DISEASES

Disease-gene associations mined from literature

Literature on PTPRA

PTPRA [ENSP00000369756]

Receptor-type tyrosine-protein phosphatase alpha; Tyrosine protein phosphatase which is involved in integrin- mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity).

Synonyms:  PTPRA,  P18433,  Q5JWG0,  Q5JWG2,  Q5JWG3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM