DISEASES

Disease-gene associations mined from literature

Literature on MGAT4B

MGAT4B [ENSP00000338487]

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B; Glycosyltransferase that participates in the transfer of N- acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis.

Synonyms:  MGAT4B,  MGAT4Bp,  hMGAT4B,  E5RFL0,  E5RFS3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM