Literature on GRK2
GRK2 [ENSP00000312262]
Beta-adrenergic receptor kinase 1; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation- independent manner . Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). ; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Synonyms: GRK2, GRK2p, hGRK2, A0A0S2Z392, ADRBK1 ...