DISEASES

Disease-gene associations mined from literature

Literature on FN3K

FN3K [ENSP00000300784]

Fructosamine-3-kinase; Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:11522682, PubMed:11975663). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions . Involved in intracellular deglycation in erythrocytes . Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines . ECO:0000269|PubMed:11522682, ECO:0000269|PubMed:11975663,

Synonyms:  FN3K,  FN3Kp,  hFN3K,  Q9H479,  Q9H479p ...

Linkouts:  STRING  Pharos  UniProt  OMIM