DISEASES

Disease-gene associations mined from literature

Literature on LILRA4

LILRA4 [ENSP00000291759]

Leukocyte immunoglobulin-like receptor subfamily A member 4; Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades . Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells . Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) . Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells .

Synonyms:  LILRA4,  LILRA4p,  hLILRA4,  A0A075B7A5,  P59901 ...

Linkouts:  STRING  Pharos  UniProt  OMIM