DISEASES

Disease-gene associations mined from literature

Literature on ADCY8

ADCY8 [ENSP00000286355]

Adenylate cyclase type 8; Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon- like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Synonyms:  ADCY8,  ADCY8p,  hADCY8,  A0A0K0K1K3,  E5RFR2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM