DISEASES

Disease-gene associations mined from literature

Literature on NAT8

NAT8 [ENSP00000272425]

N-acetyltransferase 8; Acetylates the free alpha-amino group of cysteine S- conjugates to form mercapturic acids . This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 . May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons . ; Belongs to the camello family.

Synonyms:  NAT8,  NAT8p,  hNAT8,  Q9UHE5,  Q9UHE5p ...

Linkouts:  STRING  Pharos  UniProt  OMIM