DISEASES

Disease-gene associations mined from literature

Literature on PELI2

PELI2 [ENSP00000267460]

E3 ubiquitin-protein ligase pellino homolog 2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL- 1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3- dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. ECO:0000269|PubMed:17675297, ECO:0000269|PubMed:17997719,

Synonyms:  PELI2,  PELI2p,  hPELI2,  H0YK56,  H0YNF4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM