DISEASES

Disease-gene associations mined from literature

Literature on GPC1

GPC1 [ENSP00000264039]

Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.

Synonyms:  GPC1,  GPC1p,  hGPC1,  A0A384NPH9,  C9J4Y6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM