DISEASES

Disease-gene associations mined from literature

Literature on SESTD1

SESTD1 [ENSP00000415332]

SEC14 domain and spectrin repeat-containing protein 1; May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1.

Synonyms:  SESTD1,  SESTD1p,  hSESTD1,  C9J4X8,  C9JHW6 ...

Linkouts:  STRING  Pharos  UniProt