DISEASES

Disease-gene associations mined from literature

Literature on SPAG4

SPAG4 [ENSP00000363391]

Sperm-associated antigen 4 protein; Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail.

Synonyms:  SPAG4,  SPAG4p,  hSPAG4,  C9JJZ6,  Q5JX49 ...

Linkouts:  STRING  Pharos  UniProt  OMIM