DISEASES

Disease-gene associations mined from literature

Literature on MKRN1

MKRN1 [ENSP00000255977]

E3 ubiquitin-protein ligase makorin-1; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II- dependent transcription.

Synonyms:  MKRN1,  MKRN1p,  hMKRN1,  C9IY57,  C9IZP5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM