DISEASES

Disease-gene associations mined from literature

Literature on HERPUD1

HERPUD1 [ENSP00000409555]

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway .

Synonyms:  HERPUD1,  HERPUD1p,  hHERPUD1,  H3BP08,  H3BQM2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM