DISEASES

Disease-gene associations mined from literature

Literature on MSRB1

MSRB1 [ENSP00000355084]

Methionine-R-sulfoxide reductase B1; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.

Synonyms:  MSRB1,  MSRB1p,  hMSRB1,  A0A087WXE3,  A8MYR2 ...

Linkouts:  STRING  Pharos  UniProt