DISEASES

Disease-gene associations mined from literature

Literature on ARHGEF26

ARHGEF26 [ENSP00000348828]

Rho guanine nucleotide exchange factor 26; Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.

Synonyms:  ARHGEF26,  A0A140VJU4,  Q96DR7,  Q96DR7p,  hQ96DR7 ...

Linkouts:  STRING  Pharos  UniProt