DISEASES

Disease-gene associations mined from literature

Literature on FBXO22

FBXO22 [ENSP00000307833]

F-box only protein 22; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome- dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.

Synonyms:  FBXO22,  FBXO22p,  hFBXO22,  H3BRE0,  H3BTH6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM