DISEASES

Disease-gene associations mined from literature

Literature on WDR11

WDR11 [ENSP00000263461]

WD repeat-containing protein 11; Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis . Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production . WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)- derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 .

Synonyms:  WDR11,  WDR11p,  hWDR11,  Q9BZH6,  S4R3P9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM