DISEASES

Disease-gene associations mined from literature

Literature on METTL4

METTL4 [ENSP00000458290]

N(6)-adenine-specific DNA methyltransferase METTL4; N(6)-adenine-specific DNA methyltransferase that mediates methylation of DNA on the 6th position of adenine (N(6)- methyladenosine) and is required to regulate Polycomb silencing. N(6)- methyladenosine deposition by METTL4 triggers ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing; Belongs to the MT-A70-like family.

Synonyms:  METTL4,  METTL4p,  hMETTL4,  I3L0Y1,  I3L3W2 ...

Linkouts:  STRING  Pharos  UniProt