DISEASES

Disease-gene associations mined from literature

Literature on NABP1

NABP1 [ENSP00000403683]

SOSS complex subunit B2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM- dependent signaling pathways.

Synonyms:  NABP1,  NABP1p,  hNABP1,  F8WAF5,  H7C0W4 ...

Linkouts:  STRING  Pharos  UniProt