DISEASES

Disease-gene associations mined from literature

Literature on ARIH2

ARIH2 [ENSP00000348769]

E3 ubiquitin-protein ligase ARIH2; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 . Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex . Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination . May play a role in myelopoiesis . ECO:0000269|PubMed:17646546, ECO:0000269|PubMed:19340006,; Belongs to the RBR family. Ariadne subfamily.

Synonyms:  ARIH2,  ARIH2p,  hARIH2,  C9JAU2,  C9JBC5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM