DISEASES

Disease-gene associations mined from literature

Literature on OSBPL2

OSBPL2 [ENSP00000316649]

Oxysterol-binding protein-related protein 2; Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane . Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate . Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate . Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro) .

Synonyms:  OSBPL2,  OSBPL2p,  hOSBPL2,  A0A087WTV1,  A0A087WVV0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM