DISEASES

Disease-gene associations mined from literature

Literature on ACAT1

ACAT1 [ENSP00000265838]

Acetyl-CoA acetyltransferase, mitochondrial; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA . Thereby, it plays a major role in ketone body metabolism (PubMed:17371050, PubMed:1715688, PubMed:7728148, PubMed:9744475). ECO:0000269|PubMed:17371050, ECO:0000269|PubMed:7728148,

Synonyms:  ACAT1,  ACAT1p,  hACAT1,  A0A140VJX1,  E9PRQ6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM