DISEASES

Disease-gene associations mined from literature

Literature on TNRC6B

TNRC6B [ENSP00000401946]

Trinucleotide repeat-containing gene 6B protein; Plays a role in RNA-mediated gene silencing by both micro- RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA- dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925,

Synonyms:  TNRC6B,  TNRC6Bp,  hTNRC6B,  A0A024R1N5,  B0QYM5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM