DISEASES

Disease-gene associations mined from literature

Literature on SPIRE2

SPIRE2 [ENSP00000367494]

Protein spire homolog 2; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament . Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis . Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis . Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage .

Synonyms:  SPIRE2,  SPIRE2p,  hSPIRE2,  H3BV39,  H3BV74 ...

Linkouts:  STRING  Pharos  UniProt  OMIM