DISEASES

Disease-gene associations mined from literature

Literature on CASP7

CASP7 [ENSP00000358327]

Caspase-7 subunit p11; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP- ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

Synonyms:  CASP7,  CASP7p,  hCASP7,  A0A0A0MRL7,  P55210 ...

Linkouts:  STRING  Pharos  UniProt  OMIM