DISEASES

Disease-gene associations mined from literature

Literature on ABCG1

ABCG1 [ENSP00000354995]

ATP-binding cassette sub-family G member 1; Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta- hydroxycholesterol and this transport is coupled to hydrlysis of ATP . The lipid efflux is ALB-dependent . Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta- hydroxycholesterol ; Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.

Synonyms:  ABCG1,  ABCG1p,  hABCG1,  C9JKD9,  E9PGV9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM