DISEASES

Disease-gene associations mined from literature

Literature on ACSL5

ACSL5 [ENSP00000348429]

Long-chain-fatty-acid--CoA ligase 5; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:17681178, PubMed:24269233, PubMed:22633490). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. ECO:0000269|PubMed:18806831, ECO:0000269|PubMed:19459852,

Synonyms:  ACSL5,  ACSL5p,  hACSL5,  Q9ULC5,  Q9ULC5p ...

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