DISEASES

Disease-gene associations mined from literature

Literature on NFATC2IP

NFATC2IP [ENSP00000324792]

NFATC2-interacting protein; In T-helper 2 (Th2) cells, regulates the magnitude of NFAT- driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).

Synonyms:  NFATC2IP,  H3BSZ7,  Q8NCF5,  H3BSZ7p,  hH3BSZ7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM