DISEASES

Disease-gene associations mined from literature

Literature on TPX2

TPX2 [ENSP00000300403]

Targeting protein for Xklp2; Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules . Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation . TPX2 is inactivated upon binding to importin-alpha . At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation .

Synonyms:  TPX2,  TPX2p,  hTPX2,  HCTP4,  Q643R0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM