DISEASES

Disease-gene associations mined from literature

Literature on TDP1

TDP1 [ENSP00000337353]

Tyrosyl-DNA phosphodiesterase 1; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. ECO:0000269|PubMed:15811850, ECO:0000269|PubMed:16141202,; Belongs to the tyrosyl-DNA phosphodiesterase family.

Synonyms:  TDP1,  TDP1p,  hTDP1,  A0A024R6L5,  E7EPD8 ...

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