DISEASES

Disease-gene associations mined from literature

Literature on RNF169

RNF169 [ENSP00000299563]

E3 ubiquitin-protein ligase RNF169; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.

Synonyms:  RNF169,  RNF169p,  hRNF169,  H0YEQ1,  Q8NCN4 ...

Linkouts:  STRING  Pharos  UniProt