DISEASES

Disease-gene associations mined from literature

Literature on EBF2

EBF2 [ENSP00000430241]

Transcription factor COE2; Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'- ATTCCCNNGGGAATT-3' (By similarity); Belongs to the COE family.

Synonyms:  EBF2,  EBF2p,  hEBF2,  B7Z934,  Q9HAK2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM