DISEASES

Disease-gene associations mined from literature

Literature on MICU2

MICU2 [ENSP00000371811]

Calcium uptake protein 2, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low . MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium . MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF- hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering .

Synonyms:  MICU2,  MICU2p,  hMICU2,  A0A0A0MTD5,  A0A0S2Z6V5 ...

Linkouts:  STRING  Pharos  UniProt