DISEASES

Disease-gene associations mined from literature

Literature on ZNF451

ZNF451 [ENSP00000359740]

E3 SUMO-protein ligase ZNF451; E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins . Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 . Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' . Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' . Plays a role in regulating the transcription of AR targets . ECO:0000269|PubMed:24324267, ECO:0000269|PubMed:26524493,; Belongs to the krueppel C2H2-type zinc-finger protein family.

Synonyms:  ZNF451,  ZNF451p,  hZNF451,  D6RAS1,  D6RAV4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM