DISEASES

Disease-gene associations mined from literature

Literature on ACVR1C

ACVR1C [ENSP00000243349]

Activin receptor type-1C; Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Synonyms:  ACVR1C,  ACVR1Cp,  hACVR1C,  Q8NER5,  Q8NER5p ...

Linkouts:  STRING  Pharos  UniProt  OMIM