DISEASES

Disease-gene associations mined from literature

Literature on MCM3AP

MCM3AP [ENSP00000291688]

Germinal-center associated nuclear protein; [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:23591820, PubMed:22307388). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations . ECO:0000269|PubMed:20384790, ECO:0000269|PubMed:22307388,; Belongs to the SAC3 family.

Synonyms:  MCM3AP,  MCM3APp,  hMCM3AP,  A0A0A0MSZ7,  O60318 ...

Linkouts:  STRING  Pharos  UniProt  OMIM