DISEASES

Disease-gene associations mined from literature

Literature on LIMK2

LIMK2 [ENSP00000339916]

LIM domain kinase 2; Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways . Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis by mediating phosphorylation of TPPP . Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro .

Synonyms:  LIMK2,  LIMK2p,  hLIMK2,  A0A024R1H6,  A0A024R1M2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM