DISEASES

Disease-gene associations mined from literature

Literature on BTBD7

BTBD7 [ENSP00000335615]

BTB/POZ domain-containing protein 7; Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell- scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity).

Synonyms:  BTBD7,  BTBD7p,  hBTBD7,  G3V2J4,  G3V3T2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM