DISEASES

Disease-gene associations mined from literature

Literature on PTPRE

PTPRE [ENSP00000254667]

Receptor-type tyrosine-protein phosphatase epsilon; Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). Isoform 1 and isoform 2 act as a negative regulator of FceRI- mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+); Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.

Synonyms:  PTPRE,  P23469,  Q5VWH5,  Q5VWH6,  S4R2Y5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM