DISEASES

Disease-gene associations mined from literature

Literature on PTPRR

PTPRR [ENSP00000283228]

Receptor-type tyrosine-protein phosphatase R; Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).

Synonyms:  PTPRR,  F8VU63,  F8VVE9,  Q15256,  F8VU63p ...

Linkouts:  STRING  Pharos  UniProt  OMIM