DISEASES

Disease-gene associations mined from literature

Literature on AMER2

AMER2 [ENSP00000426528]

APC membrane recruitment protein 2; Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex; Belongs to the Amer family.

Synonyms:  AMER2,  AMER2p,  hAMER2,  Q8N7J2,  Q8N7J2p ...

Linkouts:  STRING  Pharos  UniProt