DISEASES

Disease-gene associations mined from literature

Literature on DGKZ

DGKZ [ENSP00000412178]

Diacylglycerol kinase zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity . Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Activates PIP5K1A activity via generation of phosphatidic acid ; Belongs to the eukaryotic diacylglycerol kinase family.

Synonyms:  DGKZ,  E9PK94,  E9PKT3,  E9PNL8,  E9PNZ3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM