DISEASES

Disease-gene associations mined from literature

Literature on RUNX1T1

RUNX1T1 [ENSP00000402257]

Protein CBFA2T1; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes . Can repress the expression of MMP7 in a ZBTB33-dependent manner . Can repress transactivation mediated by TCF12 . Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal . ECO:0000269|PubMed:10973986, ECO:0000269|PubMed:16803958, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23812588,

Synonyms:  RUNX1T1,  RUNX1T1p,  hRUNX1T1,  A0A087WWT6,  A0A0A0MSU1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM