DISEASES

Disease-gene associations mined from literature

Literature on LRRC8C

LRRC8C [ENSP00000359483]

Volume-regulated anion channel subunit LRRC8C; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.

Synonyms:  LRRC8C,  LRRC8Cp,  hLRRC8C,  E9PHY6,  Q8TDW0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM