DISEASES

Disease-gene associations mined from literature

Literature on TIPRL

TIPRL [ENSP00000356807]

TIP41-like protein; May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine- protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.

Synonyms:  TIPRL,  O75663,  O75663p,  hO75663,  261726 ...

Linkouts:  STRING  Pharos  UniProt  OMIM