DISEASES

Disease-gene associations mined from literature

Literature on DYNLT1

DYNLT1 [ENSP00000356056]

Dynein light chain Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein. (Microbial infection) Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. ; Belongs to the dynein light chain Tctex-type family.

Synonyms:  DYNLT1,  DYNLT1p,  hDYNLT1,  P63172,  P63172p ...

Linkouts:  STRING  Pharos  UniProt  OMIM