DISEASES

Disease-gene associations mined from literature

Literature on CNOT7

CNOT7 [ENSP00000355279]

CCR4-NOT transcription complex subunit 7; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:20634287,

Synonyms:  CNOT7,  CNOT7p,  hCNOT7,  E5RGA8,  E5RGH2 ...

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