DISEASES

Disease-gene associations mined from literature

Literature on SLC26A8

SLC26A8 [ENSP00000347778]

Testis anion transporter 1; Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a molecular complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation. ; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.

Synonyms:  SLC26A8,  SLC26A8p,  hSLC26A8,  A0A024RCV0,  C9JMV8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM