DISEASES

Disease-gene associations mined from literature

Literature on VAPA

VAPA [ENSP00000345656]

Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites . The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface . With OSBPL3, may regulate ER morphology . May play a role in vesicle trafficking . ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:19289470,

Synonyms:  VAPA,  J3QKM9,  Q9P0L0,  J3QKM9p,  hJ3QKM9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM