DISEASES

Disease-gene associations mined from literature

Literature on SPAG8

SPAG8 [ENSP00000340982]

Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis . May play a role in fertility and microtubule formation through interaction with RANBP9 .

Synonyms:  SPAG8,  SPAG8p,  hSPAG8,  A0A140VJV0,  C9JAA8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM